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The extracts were mixed and concentrated under reduced pressure

Multiple mechanisms have been suggested for ES in the improvement of nerve regeneration

The key to this architecture is that the Purkinje cell stripes and their associated climbing fiber inputs operate as synchronous units [361, 362]

They revealed that only the benzamide compound BML-210 produced a significant increase of FXN mRNA expression (Herman et al., 2006), although other HDAC inhibitors showed a more pronounced increase of histone acetylation without any increase in FXN expression, indicating a degree of compound specificity for FXN gene silencing (Table 2)

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Patient-derived fibroblasts were used to interpret and analyze the applicability of this approach in a clinically relevant context