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Secreted enteric antimicrobial activity localises to the mucus surface layer

Mutations in IDO2 are common in the population, but the elevation in tryptophan, likely triggered by multiple factors such as stressors and pathogens, is rarer and is the potential cause of ME/CFS

Later complications can include liver fibrosis, cardiomyopathy, diabetes, and arthropathy

[PDF] plos.org Georgiev, Tsvetoslav, and Alexander Krasimirov Angelov