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It takes a systems biology approach to uncover the root causes of disease, often before a diagnosis is made

This may indicate that APOE4 enhances amyloid-beta burden in regions essential for cognitive domains affected in those with PD

NishimuraESHishikawaANakamichiRAkashioRChikumaSHashiguchiAet alDNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages

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