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Description

For patients who had been randomized to HTD1801, the baseline biochemical characteristics of MRI responders were indicative of more severe disease compared to MRI non-responders (Table 1)

Youngblood et al., 2020

10.1182/blood-2010-04-278614 Blood 105 TuoQ.LeiP.JackmanK

CD8 + Tcell response displayed markedly increased levels of interferon (IFN), cytolytic proteins perforin 1 (PRF1) and granzyme B (GZMB), cytotoxic T lymphocyteassociated antigen 4 (CTLA4), and tumor necrosis factor alpha (TNF

G.WangY.ShiL.WangW

Combined, these results suggest that glutathione is an important host resistance mechanism, but that also and ability to withstand host ROS, and potentially use this as a trigger for zoospore production, is important for Bd virulence