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In animal models of APAP overdose, inhibition of p53 has been shown to worsen liver injury, indicating that p53 plays a crucial role in mitigating the damage caused by APAP

After the addition of the Erastin ferroptosis inducer, the knockdown of MKL-1 did not affect the mRNA expression of ACSL4, LPCAT and ALOX-15 (Figure 4C)

The liver must also conjugate and transport processed compounds into urine or bile for final elimination

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You should also keep an eye on any redness or sensitivity around the injection site