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Mouse metabolism, mouse fat biology, and mouse dosing all differ from the human versions, and metabolic findings in rodents have a long history of not carrying over cleanly to people

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doi: 10.3389/fchem.2025.1536858 Received 29 November 2024 Accepted 27 January 2025 Published 19 March 2025 Volume 13 - 2025 Edited by Federica Aureli, National Institute of Health (ISS), Italy Reviewed by Eric Deconinck, Sciensano (Belgium), Belgium Maria Cristina Gaudiano, National Institute of Health (ISS), Italy Updates Copyright 2025 Blazewicz, Poplawska, Daniszewska, Piorunska and Karynski

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1-MNA and S-(5-adenosyl)-L-methionine (SAH) were obtained from Cayman Chemical Company (Ann Arbor, Mich., USA) 5.1 Parallel Artificial Membrane Permeability Assay (PAMPA)