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While all the kynurenines are stable in plasma for at least one year when stored at 80C (145), 3-hydroxykynurenine (HK) and to a larger extent 3-hydroxyanthranilic acid (HAA) decrease significantly in chilled EDTA and heparin blood (147), in serum and plasma at room temperature and in serum at 25C (89)

Several authors have shown that high doses of vitamin E can also interfere with drug metabolism (Galli et al., 2017)

Chem Soc Rev 50:1109811155

10.1104/pp.104.058107 95 LefevreI.GratiaE.LuttsS

doi: 10.2147/DDDT.S521265 54 FrkW.DbekB.Balcerczyk-LisM.MotorJ.RadziochE.MynarskaE.et al