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Construction of chimeric receptors between human (h) and mouse (m) and their functional analysis demonstrated that the TMD of TAS1R1 is the key domain for switching the PAM/NAM activities of methional

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Key DAMPs such as HMGB1 and ATP activate PRRs, including TLR4 and receptor for advanced glycation end products (RAGE), on macrophages, neutrophils, and fibroblasts