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Clinical studies concerning the effect of drugs modulating the insulin sensitivity (such as the peroxisome proliferator-activated receptor (PPAR)- agonists) are ongoing in order to provide new potential treatment to improve both the inflammatory status and the CV outcome in RA patients (Table 2)

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However, some reports indicate that protein and proteome abundance tends to be higher in the evening and night, whereas others find the highest protein levels during daytime hours (1.371.43 g/100 mL at 12 PM and 6 PM)

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