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NAC also maintains mitochondrial redox homeostasis by activating the SIRT3-SOD2-GPX4 signaling pathway, thus reducing the ferroptosis rate in the context of DN

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In obesity and insulin resistance, mitophagy markers, including LC3BII, Parkin, FUNDC1, and BNIP3, are generally reduced in both human and animal studies, reflecting compromised mitochondrial turnover