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Unlike endogenous cannabinoids, THC also increases mitochondrial hydrogen peroxide production [39], and reactive oxygen species (ROS) production and neuronal apoptosis in mPFC [32], a brain region critically involved in neuropsychiatric pathology

The opposite effect occurs at the adult stage (P56P70), during which wild-type mice show robust LTP and LTD compared to MET cKO mice in which LTP and LTD are markedly decreased

Kong Y, Peng Q, Lv N, Yuan J, Deng Z, Liang X, Chen S, Wang L (2020) Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimers disease via activation of adenosine A(1) receptor

doi: 10.1006/abbi.2000.2169

Effective measures for alleviating these symptoms include the administration of enemas, increased dietary fiber intake, and the use of medications to manage nausea and vomiting [28, 29]

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