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doi: 10.1002/cbdv.201900479 151 ImYRKimILeeJ

Sustaining the engine: mitochondrial quality control and transport networks As the central engine of cellular bioenergetics and intermediary metabolism, mitochondrial functional integrity is critical for sustaining high metabolic flux, anabolic potential, and therapeutic responsiveness in CRC [18]

doi: 10.1046/j.1365-2796.2000.00752.x

On the other hand, it can also cause blood-brain barrier (BBB) disruptions, persistent inflammation, neural toxic effects, and cell death in nearby areas (Galarza et al., 2020)