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Metformin pairs best with nutrition changes that emphasize protein, fiber, and steady meals

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Due to the restrictive nature and complexity of these diets, however, low histamine and elimination diets should be implemented under the supervision of a qualified nutrition professional (27)

Furthermore, metformin has been reported to reduce generation of reactive oxygen species at the complex 1 and to prevent mitochondrial-mediated apoptosis, suggesting that it can protect against oxidative stress-induced cell death