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ALCA, together with alpha-lipoic acid, was shown to improve mitochondrial energy metabolism and decrease oxidative stress leading to improved memory in aged rats [144, 145]

281 Additionally, fisetin promotes the synthesis of the antioxidant glutathione and suppresses the activity of proinflammatory factors, including TNF, IL-6, and the transcription factor NF-B

[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Liu H, Talalay P, Fahey JW

Enhanced skin hydration and barrier function

doi: 10.1128/AEM.65.8.3668-3673.1999 38 CamenzuliL.van DamR.de RijkT.AndriessenR.van ScheltJ.van der Fels-KlerxH

Whereas proteasomal degradation of the NF-B inhibitory subunit IB-, nuclear translocation of NF-B and downstream activation of the pro-inflammatory environment was inhibited when bone marrow or peritoneal neutrophils are exposed to hydrogen peroxide [108]