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In humans, the number of synapses per SNc dopaminergic neuron increases tenfold, reaching between 1 and 2.4 million synapses (Bolam & Pissadaki, 2012

and in terms of vascular barrier function, the loss of HS exposes adhesion molecules, promoting the adhesion of leukocytes and platelets, triggering inflammation and thrombosis, and further impairing renal blood supply and glomerular filtration, ultimately leading to a decrease in GFR (100)

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Food cravings have also been found to be stimulated by UPF consumption (88, 126, 131)

By integrating these holistic treatments with modern medicine, the therapeutic approach may become more comprehensive, potentially improving overall outcomes

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