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These types of defects will be much harder to develop drugs for because it would require reactivation of a non-functional allele

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10.1007/s12031-013-0031-7 214 WangY

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This enzyme, along with other gastric contents, can damage the mucous membranes and epithelial barrier it contacts, digesting intercellular connections (Reference Kowalik and Krzeski28)

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Obeid et al., 2007b), necrosis (Scaffidi et al., 2002

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PK has four subtypes, PKL, PKR, PKM1 and PKM2, among which the PKM2 subtype is generally overexpressed in various cancer cells [40]

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The inhibition of MM growth was additionally seen when co-culturing the cancer cells with human HS-5 stromal cells using a transwell model, further showing the compounds potent effect even in conditions mimicking the bone marrow microenvironment (Rogers et al., 2020)

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