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Immediately after mixing the cobalt-bicarbonate reagent with the enzyme reaction solution, its content of cobalt (II) is oxidized to cobalt (III)

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Of more than 100 compounds synthesized and tested for TGR inhibition (a more thorough description of compound design will form the basis of a future manuscript), the most promising were selected to be extensively characterized in the in vitro and in vivo studies described below

doi: 10.3390/cimb45050260 [DOI] [PMC free article] [PubMed] [Google Scholar] 185