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Lactate accumulation further suppresses cytokine production, including TNF-, IL-2, and IFN-, through interference with MAPK p38 and JNK/c-Jun signaling pathways [295]

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Barnes MA, McMullen MR, Roychowdhury S, Pisano SG, Liu X, Stavitsky AB, et al

In a comparison between T2DM patients having neuropathy, and those who do not, it was found that the first group had higher levels of B 12 deficiency than the other group [35]

Taken together, hyperhomocysteinemia is correlated with development and progression of various types of degenerative brain diseases by inducing neuronal oxidative stress and DNA damage

Then 10 M 2,7- dichlorofluorescin diacetate (DCFH-DA) was added into 4T1 cells for 30 min at 37 C