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Per the FDA-approved label, tirzepatide is titrated starting at 2.5 mg weekly and moving through 5, 7.5, 10, 12.5, and 15 mg at minimum intervals

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Learn Mem 11:447452 Miner P, Shimonova L, Khaimov A, Borukhova Y, Ilyayeva E, Ranaldi R, Bodnar RJ (2012) General, kappa, delta and mu opioid receptor antagonists mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: reciprocal and regional interactions

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