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By lowering intracellular ROS and inhibiting NF-B-dependent transcriptional priming of NLRP3, Nrf2 activity functionally lowers inflammasome formation in sterile neuroinflammatory conditions such as PD

J Neurosci Methods 314:112

Fukushima N Preprint: MEDRXIV

The transdermal composition of claim 2 which sustains constant plasma levels of GHK-Cu or copper tripeptide in an animal for at least 12 hrs after application