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Although the presence of the insulin-sensitive fat transplant might increase the FAHFAs in fat-transplanted Insr P1195L/ +/HFD mice, our present results suggest that normal glycerol metabolism in WAT is also important for the maintenance of glucose homeostasis under insulin resistance

Several findings support the hypothesis that the onset of RA is linked to the intestinal microbiota, for example that cell wall fragments from various intestinal bacteria have been found to be arthritogenic 6,7 , some drugs used to treat arthritis have antimicrobial effects (chloroquine, sulfasalazine and minocycline) 8,9,10 and the restoration of eubiosis in arthritis patients showing clinical improvement 7,11

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