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10.1248/bpb.b18-00855 61 MiyakeT.NakamuraS.ZhaoM.SoK.InoueK.NumataT.et al (2016)

Pharmacotherapy targeting the pathogenesis

Mild ischemia (CBF greater than 30 ml/100 g/min) does not normally cause cell death during the first 6 h after injury, moderate ischemia (CBF between 12 and 30 ml/100 g/min) reaches the threshold of viability in 3 h, and severe ischemia (CBF lower than 12 ml/100 g/min) causes cell death in less than an hour (Sakoh et al., 2000)

Clinical testing shows very minimal skin irritation and no evidence of sensitization or phototoxicity

There exists an imperative for additional rigorously designed clinical trials and standardized formulations to substantiate efficacy, ascertain safety, and delineate optimal dosing protocols

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