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386,387 Autophagy-inducing small molecules and natural compounds Additional autophagy-inducing agents include lithium, which induces autophagy via inhibition of inositol monophosphatase and reduces tau and amyloid- aggregation in AD models, 388 and SMER28, a small-molecule enhancer of rapamycin that promotes autophagy and reduces tau and -synuclein aggregation in AD and PD models