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Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels

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Pharmacology & Therapeutics, 46 (2), 243271

The high activity of ascorbate oxidase is responsible for lowered concentrations of the reduced form of ascorbic acid and glutathione and high content of reactive oxygen species in quiescent center cells

Psychiatry 13 , 92 (2023)

Therefore, while aware that the pharmacological modulation of the NRF2/ARE pathway could undeniably offer new therapeutic opportunities for diseases related to OS, we should at the same time consider that most of the currently known activators of NRF2 are not particularly specific, leading to an increased risk of off target toxic effects