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Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients

Hence in the deficiency of folic acid, methanol metabolism could take the alternate pathway (microsomal pathway).28 Conversion of methanol to formaldehyde (HCHO) in humans is catalyzed primarily by alcohol dehydrogenase 1 (ADH1).29 Alternative pathways of metabolism include catalase-mediated reactions, yielding formaldehyde and hydrogen peroxide.30 Formaldehyde may be the ultimate toxicant from methanol exposure

However, GSH-S-transferase A4-4 knockdown could augment 4-HNE cytotoxicity, and its overexpression could obviously inhibit 4-HNE-induced death of chondrocytes [84]