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Supplementary Figure 4 GO assignment of identified DEGs in comparisons

Bloodbrain barrier: ageing and microvascular disease systematic review and meta-analysis

Patients with PFIC3 might not show symptoms until 23 years old, unlike those with PFIC1 and PFIC2 [1, 2, 42, 44]

The peptide also prevents bacteria and toxins from entering and damaging the gut

An oxidative stress with free radicals is then induced, thereby increasing cellular death.5 Finally, a high level of ammonia in the brain may affect the autoregulation and cause hyperemia.6 Untreated, hyperammonemia can induce irreversible damage to a developing brain leading to uncontrolled seizures, motor and cognitive impairment, cerebral palsy, and/or death

Gastrointestinal protection BPC 157 was originally isolated from gastric juice and has a protective effect on the gastrointestinal tract