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1 and 2, respectively

SARS-CoV-2 nsp12 is composed of three major domains, a nidovirus RdRP-associated nucleotidyltransferase (NiRAN) domain, an interface domain and a right-handed RdRP domain (finger, palm and thumb) 111 (Fig

However, when GPx4 fails, unchecked lipid hydroperoxides undergo an iron-catalyzed breakdown into alkoxyl radicals (PLO) [47,59] , significantly expanding the oxidized lipidome as highlighted by recent mass spectrometry analyses [40,60]

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