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Pearce EN

This ferroptosisinflammationhypoxia loop ultimately converges on fibrosis progression: pro-inflammatory cytokines (e.g., from activated macrophages) and hypoxic signals synergistically activate the TGF-/SmadHDAC3 pathway, downregulating anti-fibrotic Klotho and upregulating pro-fibrotic factors (e.g., collagen I/III)