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The species cover amino acids (Ala, Arg, Asp, Asn, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val) in Figure 4b, anions (Br , Cl , ClO , CO 3 2- , F , HCO 3 , HPO 4 2- , H 2 PO 4 , I , NO 2 , NO 3 ) in Figure 4c, and cations (Al 3+ , Ca 2+ , Co 2+ , Cr 3+ , Cu 2+ , Fe 2+ , Fe 3+ , K + , Li + , Mg 2+ , Mn 2+ , Na + , Ni 2+ , Pb 2+ , Ti 4+ , Zn 2+ ) in Figure 4d

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In vivo xenograft tumors further supported this mechanism of action, indicating that caudatin treatment of tumors led to increased levels of TNFAIP1 (Tan et al., 2016) (Table 1, Row 11)