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Conflict of interest Authors WL, YW, JB, JH, and HJ were employed by Beijing Union-Genius Pharmaceutical Technology Development Co

The study protocol was reviewed and approved (approval no

In addition to diet and lifestyle changes, supplementation is a way to support the MTHFR gene mutation

Decreased activity of the mitochondrial respiratory chain was reported in overweight/obese patients with NASH compared to controls [97, 98], and alterations in mitochondrial ultrastructure have been observed prior to NAFLD development in the Otsuka LongEvans Tokushima Fatty rat [99] as well as in patients with steatosis preceding progression to NASH [100]

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LT is supported by an MS Research Australia Postgraduate Scholarship and a Byron Kakulas Prestige Scholarship from the Perron Institute for Neurological and Translational Science