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Furthermore, RS may disrupt proteasomal degradation pathways, resulting in the accumulation of damaged proteins [33] ( Table 1 )

However, GC cells frequently exhibit p53 mutations or Bcl-2 overexpression, resulting in reduced sensitivity to apoptotic stimuli, which contributes to the development of therapeutic resistance (105)

Peer review Peer review information Nature Chemistry thanks Daniel Reker and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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