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It must then bind to intrinsic factor for absorption in the intestines

Direct in vitro comparison of daratumumab with surrogate analogs of CD38 antibodies MOR03087, SAR650984 and Ab79

Reduced shedding is often the first measurable improvement

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From a research-design standpoint, this means any future genotype-by-form study must carefully hold dose and frequency constant, or those larger effects will swamp the subtler form-by-genotype signal it is trying to detect