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Ethanol metabolism produces toxic molecules such as acetaldehyde and ROS ( + /NADH ratio, changes in redox state, increased fat synthesis, hepatocellular damage, and other associated malfunctioning of metabolic activities ( Betaine supplementation was demonstrated to alleviate the alcohol-induced fatty liver in rats by improving hepatic lipid metabolism (i.e., decreasing the synthesis and increasing the catabolism) via suppression of diacylglycerol acyltransferases: DGAT1, DGAT2, sterol regulatory element binding proteins: SREBP-1c, SREBP-2, fatty acid synthase, and HMG-CoA reductase and overexpression of peroxisome proliferator-activated receptor coactivator (PGC)-1 in the liver and preventing the decline of adiponectin concentrations in serum and adipose tissue (Yang et al., 2017)

Our supplements are easily digestible, and the absorption is greatly improved over other inferior supplements

Carnitine is then shuttled back outside the mitochondria to the cytoplasm via CACT

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NC Fong, FRCPCH 2

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