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It catalyzes de novo pyrimidine ribonucleotide synthesis, and cancer cells proliferate and require more nucleotides, hence it has been investigated researched as cancer treatment [69].Metabolomic profiling studies have demonstrated the involvement of DHODH and mito-GPX4 in scavenging reactive oxygen species (ROS) and their unique roles in inducing apoptosis, irrespective of their usual function in nucleotide synthesis [18, 70]

These results reflected the imbalanced inflammation homeostasis in PDR

Microorganisms such as bacteria, viruses, and fungi can enhance the bodys immune defense against microorganisms by inducing the release of NETs from neutrophils through the activation of neutrophil receptors (TLR and NLR, etc.) and cytokines

Sheik et al

However, directed differentiation of hepatocytes remains challenging

M.van HorssenJ.AmorS.SomersV.et al