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For individuals with aberrant cycles from disrupted GnRH signaling, gonadorelin can provide a temporary means to re-impose physiological gonadotropin rhythms and facilitate timed follicle maturation

But some side effects have been reported, including: Patients with a history of melanoma may be advised to avoid peptide therapy

Reconstituted Ipamorelin has a half-life of approximately 2 hours at 25C, meaning 50% degradation occurs within the first two hours at room temperature

This tonicity is both its strength and its limitation: it dramatically simplifies the protocol (2 injections per week), but abolishes pulsatility

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Protocol cycling decisions, including continuous vs paused, are determined at the consultation based on IGF-1 response and treatment goals