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Collectively, these findings suggest that disease-associated mutations, though mechanistically diverse, converge in their impact on astrocytic reactivity by resetting the threshold at which astrocytes enter reactive states

Additionally, further exploration of the bidirectional communication within the axis particularly the impact of hypothalamic stress signaling on gut microbiota remains essential

Double-edged roles of ferroptosis in endometriosis Endometriosis is also an oestrogen-dependent gynaecological disease in which excessive oestrogen signalling transduction and altered oestrogen signalling pathways play an important role in its pathogenesis, resulting in oestrogen dominance and progesterone resistance [97, 98]

Because the underlying factors that cause hair loss, like genetics and hormones, are often ongoing, the treatment works best with a long-term plan