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2021 Jan 29;13(2):447

J Biol Chem 282 : 3177731788

The assay involved coating the wells of a microplate with monoclonal antibodies against rat IL-1

Modig K Article: HUMAN MUTATION

This event is followed by the generation of ROS from the oxidation of FADH2 as induced by the demethylase, with consequent oxidation of nearby guanines (8-oxo-Gs) and recruitment of DNA repair enzymes (among which is APE1) that cause single-strand breaks in DNA and enable looping between the enhencer/promoter and the polyadenylation sites of the target genes, with productive transcription 140,141