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In particular, BPC 157 increases the expression and internalisation of VEGFR2, the activation of the VEGFR2-Akt-eNOS signalling pathway without the need for other known ligands or shear stress[63], and heals corneal ulcer and lesions while maintaining corneal transparency[55,68], much like it heals lesions in the entire gastrointestinal tract[14-16,27,28,52-54] and other tissues, gastrointestinal fistulas in particular[21-25,56]

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USA 86 , 76537657 (1989)