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The adverse effects of diabetes extend beyond the endothelium, as hyperglycemic conditions impact microglia activation, leading to increased proinflammatory cytokine production and ROS formation in both the endothelium and parenchymal microglia

For example, GPX4, a key factor in the antioxidant system, also inhibits apoptosis and necroptosis to protect cells from various insults [129, 130]

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After complete denaturation, 100 uL of the biomolecule solution is added to 0.8 mL of the previously prepared gold nanoparticle solution

There it also inactivates reactive intermediate products resulting from the metabolisation of certain drugs