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Recent research into ME/CFS investigates increased kynurenine production rather than decreased levels proposed by the metabolic trap hypothesis. The balance between tryptophan depletion and kynurenine generation, marked by the kynurenine and tryptophan (KYN/TRP) ratio, indicates IDO activity and immune responses

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As with many other disorders, factors such as nutritional status, neurotransmitter metabolites, oxidative stress, and environmental influences affect the metabolic profile in ASD (Zurawicz et al