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Low glutathione levels correlates with poor survival in AIDS patients

It is not approved for human use, compounding through 503A/503B pharmacies, or any clinical purpose outside of registered trials

However, when intracellular ROS are increased, Trx is oxidized, thus leading to the dissociation of TXNIP from Trx, which subsequently interacts with NLRP3, leading to the assembly and activation of the NLRP3 inflammasome (84, 85)

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Subsequently, ROS harm cells by damaging important components like DNA, lipids, and proteins, which worsens the condition of already compromised neurons