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Many transgender persons have reported significant levels of depression, anxiety, social isolation, and even suicidal ideation

A 50-year-old with heart disease might be at elevated risk and need a different strategy

Its global incidence amounts to millions of individuals [1], possibly 1% of populations, and even 20 years ago, its cost represented some 1% of the NHS budget, with all these numbers on a rising trend [6,7,8,9], albeit with large regional differences of incidence and/or reporting (e.g., South Asia is said to be 12 lower than North America [10])

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That gap is why every figure in this guide is presented as a documented research protocol rather than clinical guidance

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