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6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a crucial glycolytic regulator, converts fructose-6-phosphate to fructose-2,6-bisphosphate (F2,6BP), enhancing PFK-1 activity and thus promoting EC proliferation, migration, and angiogenesis [23]

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