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The companies saw potential in using AOD-9604 as a cosmeceutical producta blend of cosmetic and pharmaceutical properties

NNMT inhibition increases intracellular concentrations of NAD + and SAM in differentiated adipocytes Figure 3A outlines the major elements of the mammalian NAD+ salvage pathway using NA as the starting substrate.[27] Since the NNMT inhibitor 5-amino-1MQ significantly reduced intracellular 1-MNA concentrations (Figures 2B and 2C), we hypothesized that NNMT inhibition in adipocytes would increase intracellular concentrations of the co-substrates NA and SAM and shunt more NA into the NAD + salvage cycle

Genuine choline deficiency contributes to hepatic fat accumulation which is exactly why choline is in the blend and why the fat-metabolism story sounds plausible

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J Neurosci