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It combats oxidative stress and neutralizes harmful free radicals, but our natural production decreases with age

Onodera Y, Motohashi H, Takagi K, Miki Y, Shibahara Y, Watanabe M, Ishida T, Hirakawa H, Sasano H, Yamamoto M, Suzuki T (2014) NRF2 immunolocalization in human breast cancer patients as a prognostic factor

Ketosis may be the result of human evolution and may be strongly tied to a time when food scarcity occurred the majority of the time

Y.WuC.et al

Marked intracerebral bleeding was seen in the area of the corpus callosum, amygdala, thalamus, neocortex, and striatum

Compromised GSH concentrations and diminished redox status in humans occurs over age 45, and A precipitous decline in GSH/GSSG redox occurs, along with a linear oxidation of cysteine/cystine redox state with age at a rate of 0.16mV/year over the entire age span (in plasma), GSH/GSSG redox was not oxidized prior to 45 years and subsequently was oxidized at a nearly linear rate of 0.7 mV/year