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In the initial dose-finding studies, three concentrations of Cagrilintide ranging from 3, 30, and 300 nmol/kg, were tested in chow-fed WT mice

PMID 28678785

Because the peptide potently and aggressively stimulates angiogenesis via the VEGF/VEGFR2 pathways, there is a theoretical, but highly biologically plausible, risk that BPC-157 could inadvertently supply massive new blood flow to existing, undiagnosed malignant tumors, thereby acting as a catalyst for rapid cancer metastasis

However, since the liver enzyme (AST and ALT) levels were similar in the standard and low IGF-1 groups in this study, we suspected that such influences would have been minimal

doi:10.1182/blood.V48.1.53.53

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