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110,111 Despite GSKs attempts to gain a competitive edge through low pricing, Tanzeum failed to achieve sufficient market acceptance

In contrast to the central nervous system (CNS) which is well protected by a bloodbrain barrier, the sensory neurons and axons in the peripheral nervous system (PNS) are more susceptible than the CNS to damage from chemotherapy drugs, due to the absence of an effective blood-nerve barrier in the PNS (Starobova and Vetter, 2017)

But for routine wellness, the marginal benefit is uncertain and may not justify the cost and risk

Pullarkat V, Blanchard S, Tegtmeier B, Dagis A, Patane K, Ito J, et al Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation Bone Marrow Transplant

10.1161/CIRCRESAHA.118.313142 79

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