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10.1038/nchembio.2238 210 KalyanaramanB

In 1999, a rare ApoE4 mutant, APOE4 -L28P Pittsburgh variant, in which the substitution from leucine to proline occurs at position 28 of APOE4 , was discovered in the heterozygous form when screening the ApoE mutants in white LOAD patients who were from Pittsburgh, Indiana, and Mayo Clinic Rochester (Kamboh et al., 1999)