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Conflict of interest EB and GT were employed by PharmaNutra S.p.A, Pisa, Italy

What is vitamin B12 (cyanocobalamin) used for

Cyanocobalamin is a synthetic form, widely available and effective

Dosage adjustments often become necessary with oral forms to compensate for reduced bioavailability, which can introduce variability and complexity into research

Route/evidence mismatch: the pivotal mouse study tested subcutaneous injection at a fixed research dose (20 mg/kg, three times daily) the oral capsule use that is actually sold and discussed commercially has not itself been directly tested in that published research

Some individuals notice improvements within days, while others experience gradual changes as nutrient levels stabilize