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2019 [cited 2019 Jun 9]

But those trials were small (approximately 300 subjects total across phases), short (up to 24 weeks), and used a route of administration that likely delivered minimal systemic exposure

Pain relief does not always happen immediately

26 Other possible mechanisms include improvements in mitochondrial function and a reduction of glutamate, an excitatory neurotransmitter, which is also a precursor to GSH